ABSTRACT
<p><b>Objective</b>To investigate the relationship of the characteristics of sperm donors with the results of screening and provide some reference for the screening of sperm donors.</p><p><b>METHODS</b>We statistically analyzed the screening data about 12 362 sperm donors at the Guangdong Human Sperm Bank from January 2003 to June 2017 and the relationship of the eligibility rate of screening with the donors' age, education, occupation, marriage, and fatherhood.</p><p><b>RESULTS</b>Of the 12 362 sperm donors, 3 968 (32.1%) met the standards of semen quality and 3 127 (25.3%) filled all the requirements of sperm donation. The eligibility rate of screening was 27.7% in the donors aged 20－24 years, 24.3% in those aged 25－29 years, 23.8% in those aged 30－34 years, and 17.5% in those aged =≥35 years (P < 0.01); 23.5% in the senior high school students, 24% in the junior college students, 25.9% in the undergraduates, and 30.3% in the postgraduates (P < 0.01); 29.3% in the students versus 22.9% in the others (P < 0.01), 41.5% in the married versus 20.7% in the unmarried (P < 0.01), and 45.6% in the fathers versus 20.9% in the childless husbands (P < 0.01).</p><p><b>CONCLUSIONS</b>A higher eligibility rate of screening was found among the sperm donors aged <35 years or with a bachelor's or higher degree, particularly among students.</p>
Subject(s)
Adult , Humans , Male , Young Adult , Semen Analysis , Reference Standards , Spermatozoa , Students , Tissue Donors , Tissue and Organ ProcurementABSTRACT
<p><b>OBJECTIVE</b>To evaluate the effect of treatment for tonifying qi, nourishing yin, activating blood circulation and removing stasis on insulin resistance (IR) in patients of type 2 diabetes mellitus (T2DM) complicated with hypertension.</p><p><b>METHODS</b>Forty-five patients of T2DM with hypertension enrolled from authors' special clinics were equally randomized into two groups: the test group (20 patients) and the control group (25 patients). Both groups received orally hypoglycemic drugs, such as glipizide sustained-release tablets, pioglitazone, and metformin, and antihypertensive drug as nifedipine sustained-release tablets as well. Additionally, Sanqidan Granules (SQD), a Chinese patent medicine was given to the test group. The course of treatment lasted for 8 weeks. The clinical efficacy of Chinese medicine syndromes, blood pressure, T2DM related indices and blood lipids in the two groups were observed.</p><p><b>RESULTS</b>The effect in improving Chinese medicine syndromes in the test group was better than that in the control group significantly (P <0.05). After treatment, all the indices were examined, except FINS and TG were improved in the test group, showing significant difference as compared with those before treatment; while in the control group, significant difference was only shown in terms of fasting blood glucose (FBG), HbA1 c, systolic blood pressure (SBP) and HDL-C (P <0.01). Comparison between groups showed that the effect in the former was better than that in the latter group in terms of decreasing FBG, HbA1c, SBP and increasing of HDL-C (P <0.05), while a downward trend of ISI in the test group was shown but with no statistical significance (P = 0.230).</p><p><b>CONCLUSIONS</b>SQD can relieve the clinical symptoms in patients of syndrome of qi-yin deficiency and inner blockage of blood stasis, increase the insulin sensitivity and reduce the IR in patients, so as to decrease their FBG, blood pressure and HbAlc. It also can increase HDL-C level, and lower TC and LDL-C levels, which is beneficial to anti-atherosclerosis.</p>